Hair Loss (Formula 82m)
A Uniquely Engineered Formulation Providing An Alternative Solution For Hair loss
Minoxidil has been the number one topical therapy for androgenetic alopecia since its FDA clearance in 1988. Even after years of use, its exact mode of action is not completely understood. Minoxidil sulfate is the active metabolite which has been shown to stimulate hair growth. The proposed mechanisms of action for minoxidil are:
- It creates vasodilatation.
- It slows aging process of keratinocytes.
- It increases proliferation of dermal papilla cells in the hair follicle.
- It enhances cell proliferation.
Increased Efficacy With Tretinoin And Minoxidil
There is also evidence that tretinoin, when added to minoxidil, can increase its efficacy. Studies have shown that tretinoin increases the percutaneous absorption of minoxidil by 3 fold. Intriguingly, in one study by Lewenberg, it was noted that while minoxidil appears to exert its best hair growing effects on the vertex of the scalp, the combination of tretinoin and minoxidil “results in hair growth in all areas of the scalp.” The mechanism of action for hair growth from tretinoin is not clear either. It has been shown to penetrate the nucleus of cells and induce protein synthesis and cell turnover. Additionally, it prolongs cell survival and prevents apoptosis of dermal papilla cells. The use of topical steroids has been shown to decrease inflammation associated with the use of minoxidil, trentinoin or the combination of both. Also, the combination has been shown to have increased efficacy over minoxidil alone.
In 2008 a group of 5 dermatologists in Mexico headed by Dr. Antonio Cueva introduced these formulas to Mexico. They performed some clinical trials showing a markedly faster onset of hair growth and more profound hair growth than they had seen with previous minoxidil based formulas. The photos document several cases showing the rapid and dramatic results of the use of the these products.